First, man’s relationship to God was reversed.
When Adam and Eve were originally created God intended for them to be servants in fellowship. Adam was placed in the Garden of Eden in order to cultivate it and keep (guard) it (Gen 2:15). But now he becomes the rebel in fear (Gen 3:10). Adam and Eve hid from the presence of the Lord because they were afraid. Men often fear the presence of God because they are afraid of his judgment and condemnation.
Second, man’s relationship to the created universe is reversed.
We were put in charge of this earth to have dominion over it and subdue it (Gen 1:27-28). The original creation order was God—Man—World. The temptation from Satan was a lie from the beginning. He promised Adam and Eve that they could take God’s place in this order (Man—God—World). But in reality we were lowered to the status of a servant for creation; God—World—Man. We are destined to work by the sweat of our brow (Gen 3:19) and to serve the ground (Gen 3:23).
Third, our relationship with death is reversed.
Death was not part of God’s original creation. We are not getting into animal death here. I am simply talking about human death. It came in through sin (Rom 5:12). In the Biblical view death is a dirty intruder who needs to be done away with (1st Cor 15:54-56). Death is not consigned to that moment when our physical bodies give out. Death is both spiritual and physical. Whereas before we had access to the tree of life, now we are barred from the tree. At one time we were alive but when we became sinners we died spiritually (Rom 7:9) and one day we will die physically.
Fourth, there is a reversal in our worship.
Obviously we were supposed to worship the only true God (Matt. 4:10). But man suppressed the truth in unrighteousness, turning to serve and worship the creature rather than the Creator (Rom 1:21-23). Even today, in post-modern America, we worship the creation. The theory of evolution has hijacked phrases due to God the Father and attributed them to Mother Nature. For example, “nature, in her wisdom…”, “nature selected…”, “mother nature provided…”. We have attributed to creation the characteristics of God.
Fifth, the world has become evil and must be avoided.
I am not contending for the ascetic life living in a cave. My point is that we are not to think this world is our friend. Our environment is, not inherently, but as it currently stands, antagonistic. Nature is a harsh ecosystem that must be navigated with the utmost caution. This is not a paradise to be enjoyed but an environment to be endured.
Sixth, and finally, creation itself groans under it’s unnatural burden (Rom 8:20-22).
There is a great debate over the age of the universe. Modern scientific interpretation seems to clearly point to an old universe. But the often overlooked presupposition is that the universe we currently view is not the same universe God originally created. It has been tainted, corrupted, changed, and put under a curse. It awaits its own restoration (Matt. 19:28; Acts 3:21; 2nd Peter 3). We are looking into the side mirror of our car seeing a vehicle in the distance but missing the caution that "objects are closer than they appear". The universe we live in today is the same one created by God.
Sin has done damage but not irreparable damage. God has judged sin and will one day restore everything back to its rightful place. Can you think of any other ways sin effected the Creation order?